拉氧头孢治疗新生儿感染性肺炎疗效观察

Effect of Latamoxef in treatment of neonatal infections pneumonia

目的探讨拉氧头孢治疗新生儿感染性肺炎的疗效。方法按随机原则将100例新生儿感染性肺炎病例分为2组,治疗组(n=50),用拉氧头孢40～80mg/(kg.d),静脉滴注1次/12h,疗程5～14d,对照组(n=50),采用传统治疗方法(包括用头孢噻肟、头孢曲松及头孢他啶),50～100mg/(kg/d),静脉滴注,疗程5～14d,比较2组临床症状(包括气促、口吐泡沫、咳嗽、发热、肺部啰音)消退时间、住院天数及临床疗效。结果临床症状消退时间、住院天数2组比较均差异有统计学意义(P均<0.01),治疗组总有效率为86.0%,对照组总有效率为64.0%,治疗组优于对照组(P<0.01),且未发现明显不良反应。结论拉氧头孢治疗新生儿感染性肺炎疗效明确,值得临床推广应用。

Objective To investigate the effect of Latamoxef in treatment of neonatal infections pneumonia.Methods 100 neonates with infections pneumonia were randomly divided into two groups.Treatment group（n=50）,treated with Latamoxef 40～80 mg/（kg·d）,intravenous infusion q12 h,treatment 5～14 d.Control group（n=50）,used the traditional treatment methods（including Cefotaxime,Ceftriaxone and Ceftazidime）,50～100 mg/（kg·d）,intravenous drip treatment 5～14 d,Clinical symptoms subsided time,（including shortness of breath,vomit foam,cough,fever,pulmonary rales）and hospital days and clinical efficacy were compared between the two groups.Results Clinical symptoms subsided time and hospital stay two groups were significantly different（P0.01）,total effective rate was 86.0% in the treatment group,the total effective rate was 64.0% in the control group（P0.01）,and no obvious adverse reactions.Conclusion The effect of Latamoxef in treatment of neonatal infections pneumonia is clear,worthy of clinical application.