抑郁症患者丘脑磁共振波谱研究

Studies of the MRS of the thalamus in patients with depression

目的研究抑郁症患者丘脑是否存在代谢异常。方法应用质子磁共振波谱分析技术检测14例未用药首发抑郁症患者和16例健康志愿者丘脑的多个代谢指标,包括N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌醇(MI)等。结果病例组右丘脑等部位的Cho、NAA含量明显低于对照组(P<0.05);病例组右侧丘脑MI含量与HAMD评分成正相关(P<0.05)。结论抑郁症患者右丘脑的Cho含量明显低于对照组,提示脑部Cho含量的改变与抑郁症患者情感症状相关;NAA含量明显低于对照组(P<0.05),提示抑郁症患者这些部位的神经元受损较明显。郁症患者右丘脑MI含量与HAMD评分呈正相关,提示MI在抑郁症发病中有重要作用,尤其是右丘脑MI水平与抑郁症发病关系密切,且对抑郁症诊断及严重程度的判断具有一定指导意义。

Objective To find the metabolic changes in different brain regions of patients with depression.Methods 1H-MRS was performed on the thalamus in 14 patients with depression and 16 control.Cho,NAA and MI were calculated respectively.Results Metabolic ratios compared between the patients and controls showed the Cho and NAA levels of right thalamus of the patients were significantly lower than the controls（P0.05）.Correlative analysis showed that MI scales in the right thalamus were positively related to the HAMD scales in the right thalamus（P0.05）.Conclusion The depressive patients have lower level of Cho in the right thalamus suggested the decrease of Cho of these regions should be related to the affective symptoms of depression.The depressive patients had lower higher of NAA in the right thalamus suggested that the neurons of these regions should be significantly damaged.The positive correlation between MI and HAMD scales in the right thalamus suggested that MI should play an important role in the pathogenesis of depression.The MI level of the right thalamus has close relationship with the depression,and has great value in diagnosing depression.