纳络酮联合复方丹参治疗新生儿缺氧缺血性脑病的疗效观察

Clinical observation of hypoxic ischemic encephalopathy with Naloxone and Danshen in newborn

目的观察纳络酮联合复方丹参治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法将74例HIE患者随机分为两组,对照组36例采用镇静、止惊、降颅压、纠正酸碱失衡及代谢紊乱、脑代谢激活剂等治疗,治疗组38例在上述治疗基础上联合应用纳络酮、复方丹参静脉滴注。结果治疗组的有效率94.7%,明显优于对照组的75.0%,两组差异有统计学意义(P<0.05)。结论纳络酮联合复方丹参治疗HIE,疗效好,病程短,值得临床推。

Objective To observe the curative effect of combined treatment by Naloxone and compound Danshen on hypoxic ischemic encephalopathy in newborn.Methods All together 74 newborns with hypoxic ischemic encephalopathy were divided into two groups randomly.Both groups received the conventional treatments：sedation,scare ceasing,intracranial pressure reducing,acid base imbalance,and metabolic disorders,brain metabolic activation agent therapy.Additionally,the observation group（38 infants） were assistedly-treated with Naloxone ketone and compound Danshen intravenous drip.Results The symptoms and body signs disappearing lead time of the observation group was less than the control group（P0.05）.Conclusion Naloxone and Danshen is effective and reliable in treatment of neonatal hypoxic ischemic encephalopathy.