385例男性不育患者精液病原菌分布及耐药性分析

Distribution and drug resistance of pathogen in semens of 385 cases of male infertility

目的了解男性不育患者精液中病原菌分布及耐药情况,为临床治疗提供可靠依据。方法对385例深圳市观澜人民医院男科门诊就诊的不育患者进行精液细菌学检查,分析其病原菌分布及耐药情况。结果不育男性精液中细菌感染率为44.2%,其中革兰阳性菌占86.5%,以表皮葡萄球葡菌、金黄色葡萄球菌、溶血葡萄球菌为主,革兰阴性菌占13.5%,以肠杆菌科细菌为主;葡萄球菌属细菌对青霉素G及红霉素耐药率较高,分别为93.6%和56.0%,革兰阴性菌对哌拉西林耐药率较高,为72.0%。结论男性不育患者精液的细菌感染率、耐药率较高,且细菌种类在不断发生变化,这是导致男性不育的一个重要原因。

Objective To understand the distribution and drug resistance of the pathogen in the semens of male infertility patients and provide reliable basis for clinical treatment.Methods 385 cases of male infertility outpatients were studied;the pathogenic bacteria distribution and drug resistance were analyzed.Result The bacterial infection rate of infertile men’s semens was 44.2%,in which gram-negative organisms accounted for 86.5% with Staphylococcus epidermidis,Staphylococcus aureus and Hemolysis staphylococcus being predominant,while gram-negative bacteria accounted for 13.5 percent with Enterbacteriaceae being predominant.Staphilococci bacteria showed higher resistance to penicillin G and erythromycin（93.6% and 56.0% respectively）,while gram-negative organisms were more resistant to piperacillin（72.0%）.Conclusion The bacteria infection rate and resistance rate of male infertility patients’ semens are high with the bacteria species constantly changing,which is an important reason of male infertility.