重组人生长激素在腹部重度创伤患者中的早期价值探讨

目的通过回顾性研究来探讨重组人生长激素(rhGH)治疗腹部重度创伤的早期价值及临床意义。方法 2005年1月至2010年12月,26例重度腹部创伤患者分为A组(n=12)和B组(n=14),A组接受肠外营养联合rhGH治疗,B组接受肠外营养治疗,通过监测住院期间2组患者的血糖、甘油三脂(TG)、蛋白质代谢指标、免疫指标的改变和观察2组患者并发症的发生情况,比较2种治疗方法对患者蛋白质代谢和免疫功能的影响。结果与B组相比,肠外营养联合rhGH组(A组)患者治疗后第4、7天蛋白质代谢指标、免疫指标明显改善,术后并发症的发生率较低(P<0.05)。而2组血糖和TG在治疗前和治疗后4、7d监测显示差异无统计学意义(P>0.05)。结论早期联合rhGH肠外营养是治疗重度腹部创伤的一种安全有效的治疗措施,加用rhGH能更好地改善患者预后,有利于患者康复。

Objective To observe the effects of parenteral nutrition combined with recombinant human growth hormone（fhGH）support on immunologic function and protein metabolism in early severe abdominal trauma and clinical significance.Methods twenty-six cases of severe abdominal trauma were divided into control group（n=12）and study group（n=14）,treated with parenteral nutrition,and parenteral nutrition combined with rhGH,respectively.The blood glucose level,TG,indexes of protein metabolism,immune indexes and complicarlons were analyzed.Results Indexes of protein metabolism and immune indexes in study group were obviously improved as compared with control group on the day 4 and 7 after the treatment（P0.05）,and the incidence of complications in study group was lower than in control group（P0.05）.However,there Was no significant diference in the blod glucose level and TG before and 4,7 days after the treatment（P0.05）.Conclusion The parenteral nutrition support combined with rhGH is a safe an d efective method for postoperative support in severe abdominal trauma and it can improve prognosis and is beneficial to the rehabilitation of the patients.