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血清脑钠肽对慢性肾脏病患者舒张性心功能不全的诊断价值 被引量:7

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摘要 目的:探讨合并舒张性心功能不全(DHF)的慢性肾脏病(CKD)非透析患者血清脑钠肽(BNP)浓度水平变化及其临床意义。方法:80例经超声心动图检测左室射血分数(LVEF)正常(LVEF≥50%)的CKD非透析患者(K/DOQI分期3~4期),按二尖瓣舒张期E峰与A峰流速比值(E/A)分为心功能正常组(E/A≥1)24例,DHF1级组(0.8≤E/A<1)18例,DHF2级组(0.6≤E/A<0.8)25例及DHF3级组(E/A<0.6)13例,ELISA法检测各组血清BNP浓度水平,并与20例正常对照组做比较。结果:与对照组相比,CKD患者心功能正常组、DHF各级组BNP浓度均增高(均P<0.01);与心功能正常组相比,DHF各级组BNP浓度均增高(均P<0.01);且随着舒张性心功能恶化,BNP水平呈逐渐上升趋势;相关分析显示BNP浓度与E/A值呈负相关(r=-0.603,P<0.01)。结论:BNP浓度水平与CKD非透析患者DHF相关,临床测定BNP水平并结合超声心动图有助于对此类患者DHF的综合评估。
出处 《实用医学杂志》 CAS 北大核心 2011年第18期3352-3354,共3页 The Journal of Practical Medicine
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参考文献10

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二级参考文献21

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