耐药菌监测与抗菌药物合理应用

目的了解我院细菌耐药流行趋势及抗菌药物应用现状,为临床合理使用抗菌药物提供依据。方法收集我院2010年1至12月份临床分离菌株184株,对其病原菌构成、药敏试验结果进行统计,进行数据分析。利用限定日剂量(DDD)计算抗菌药物使用频度。结果药敏结果显示:G-菌对亚胺培南、头孢哌酮舒巴坦最敏感。其他部分耐药率>75%,G+菌对万古霉素、头孢哌酮舒巴坦最敏感,部分其它耐药率>50%,抗菌药物DDDs排名前五位是:阿莫西林克拉维酸钾、头孢哌酮舒巴坦、青霉素、氨苄西林舒巴坦、美洛西林钠。结论阿莫西林克拉维酸钾的使用频度与细菌耐药成正比,临床应注意β-内酰胺类药物的正确使用,同时对G-菌、G+菌均敏感的药物头孢哌酮舒巴坦应采取保护措施,以延缓耐药性的产生。

Objective to know the popular trend of resistant bacteria and antimicrobial application present situation,for clinical rational use of antimicrobial agents,provides the basis.Mettods we collected from year 2010 1-December 184 plants,clinical separation strains of the pathogen structure,the results of drug sensitive test statistics,analyzes the data. Using limit daily dose （DDD） ealcniation antlmicrobial use frequency.Results the results showed that：drug susceptibility G strains of imipenem,cefoperazone sulbactam the most sensitive.The other part of the resistance,G ＋ bacteria〉75% to vancomycin, cefoperazone sulbactam the most sensitive part of another〉50%,respectively,antibacterial drugs DDDs ranked in the top five is：amoxicillin clavulanic acid potassium,cefoperazone snilbactam,peniciUin,ampiciUin sulbactam and mezlecillin sedium.Conclusion amoxiciUin clavnianic potassium use frequency is proportional to the bacteria and drug resistance,clinical should pay attention to in the proper use of system drugs,and the G-bacteria,G ＋ microbes were sensitive drug cefoperazone snibactam should take protective measures,to delay the generation of drug resistance.