七叶皂甙钠联合阿司匹林预防脑梗死复发疗效观察

Aescin in Combination with Aspirin to Prevent Recurrence of Cerebral Infarction Observation

目的观察七叶皂甙钠联合阿司匹林预防脑梗死复发的临床疗效。方法 80例脑梗死患者随机分为治疗组和对照组2组,每组各40例。2组均根据病情给予降压、降糖、降血脂等常规治疗,治疗组采用:β-三七总皂甙0.5g/d,每日3次口服,肠溶阿司匹林75mg/d,每天1次。2组疗程均为15d。观察治疗前后的临床疗效及复发情况。结果 2组治疗过程中未见出血等副作用及不良反应。治疗组的有效率为92.5%,对照组有效率为72.5%,2组总有效率比较,治疗组明显优于对照组(P<0.05)。且治疗组神经功能缺损程度评分治疗后明显降低,明显低于对照组,差异有显著性(P<0.05)。且随访2～3年,治疗组的复发率为5%,对照组的复发率为20%,治疗组的复发率明显低于对照组(P<0.05)。结论应用七叶皂甙钠联合阿司匹林治疗脑梗死疗效确切,无明显不良反应,复发率低,适合基层医院广泛推广。

Objetive Aescin combination with aspirin for prevention of cerebral infarction recurrence of clinical efficacy. Methods 80 patients with cerebral infarction were randomly divided into treatment group and control group,40 patients in each group.Both groups were given the condition of patients blood pressure,glucose,cholesterol,and so conventional therapy,the treatment group were β-PNS 0.5g/d,3 times a day orally,enteric--coated aspirin 75mg/d,eaeh Day 1.The treatment lasted 15 days.Before and after treatment the clinical efficacy and recurrence.Results There were no bleeding during the treatment side effects and adverse reactions.The effective rate in treatment group 92.5%,control group was 72,5%,tetal effective rate between the two groups,treatment group was significantly better than the control group （P〈0.05）. And the treatment granp,neurologicol deficit scores significantly decreased after treatment was signifieantly lower than the control group,the difference was significant （P〈0.05）.And follow--up 2-3 years,the treatment group the recurrence rate was 5% in the control group, the recurrence rate was 20%,the treatment greup,the recurrence rate was significantly lower than the control group （P〈0.05）.Conclusion Aescin treatment of cerebral infarction is effective in combination with aspirin, no significant adverse reactions,relapse rate,widely promoted for primary hespital.