心脏再同步化治疗对心力衰竭患者血浆脑钠肽水平及心功能的影响

Effects of Cardiac Resynchronization Therapy on Plasma Level of Brain Natriuretic Peptide and Cardiac Function in Patients With Heart Failure

目的:观察心脏再同步化治疗(CRT)对心力衰竭患者血浆脑钠肽(BNP)水平及心功能的影响。方法:选择因顽固性心力衰竭行CRT术患者17人,分别于术前及术后6、12月测定血浆BNP水平,并行超声心动图检查,评估心脏功能。结果:CRT术后6、12个月的血浆BNP水平较术前明显降低(P<0.05),术后6、12个月患者的左室射血分数(LVEF)明显升高(P<0.05),左室舒张末期内径(LVEDD)减小(P<0.05)。Pearson相关分析示,BNP与LVEF呈负相关(r=-0.653,P<0.05),BNP与LVEDD呈正相关(r=0.608,P<0.05)。结论:对于心力衰竭患者,CRT能够明显降低患者的血浆BNP水平,改善其心功能;血浆BNP水平能够反应患者术后心功能情况。

Objective： To observe the effects of cardiac resynchronization therapy （CRT） on plasma level of brain natriuretic peptide （BNP） and cardiac function in patients with heart failure. Methods： Seventeen patients refractory heart failure underwent CRT were enrolled. Plasma levels of BNP were determined before CRT, 6 months after CRT. Cardiac function was evaluated also by echocardiography. Results： Plasma level of BNP was gnificantly decreased, left ventricular ejection fraction （LVEF） was remarkably increased, while left ventrieular end diastolic diameter （LVEDD） was shortened at 6 and 12 months after CRT compared with those before CRT （P〈0. 05）. Pearson analysis showed that BNP was negatively related to LVEF （r = - 0. 653, P%0. 05）, and was positively related to LVEDD （r = 0. 608, P〈0. 05）. Conclusions. CRT might significantly reduce plasma level of BNP and improve cardiac function in patients with heart failure. Plasma level of BNP could reflect patients＇ left ventricular function after CRT.