ED与血脂异常相关性及2种干预方式对比研究

CORRELATION BETWEEN DYSLIPIDEMIA AND ERECTILE DYSFUNCTION AND COMPARISON OF 2 INTERVENTION METHODS

目的探讨血脂异常与勃起功能障碍(erectile dysfunction,ED)的相关性,及2种干预方式疗效的对比。方法应用临床流行病学研究方法,比较有血脂异常者150例ED发病情况和血脂正常男性150例ED的发病情况,并分析空腹三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low densitylipoprotein-C,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein-C,HDL-C)与ED的关系。对血脂异常150例中ED患者82例用2种方法干预,服用降脂药物、性功能康复和改变生活方式,观察ED的改善情况。结果血脂异常者ED的发病率为54.6%,血脂正常者为12.6%,两者差异有统计学意义(P<0.005)。Logistic回归分析发现HDL-C、TC/HDL-C、与ED的发病有关,除HDL-C为保护因素,其余均为危险因素。TC与ED的严重程度呈正相关(r=0.218,P<0.005),LDL-C值与ED的严重程度呈正相关(r=0.322,P<0.005),TG与ED的严重程度呈正相关(r=0.293,P<0.003),HDL-C与ED的严重程度呈负相关(r=-0.467,P<0.005)。服用降脂药物、性功能康复,和生活方式改变都可以提高ED患者的国际勃起功能指数-5评分,二者差异无统计学意义(P>0.05)。结论血清高TC、高LDL-C和低HDL-C与ED密切相关,血脂异常是继发性ED的主要致病因素之一,通过降脂治疗、性功能康复和改变生活方式都可以改善ED。

Objective To investigate the correlation between dysfunction（ ED ）, and compare two methods of intervention. Methods dyslipidemia and erectile The clinical epidemiologic method was used to compare the ratio of ED in 150 patients of dyslipidemia to 150 healthy individual, meanwhile analyzed the relationship of ED and lipid profile Total cholesterol （ TC）, triglyceride （ TG）, low density lipoprotein - c （ LDL - C ）, high density lipoprotein - C （ HDL - C ）, and then the 82 ED patients of 150 dyslipidemia patients were treated with two ways that were sexual function rehabilitation and changing lifestyle. Results The ratio of ED in dyslipidemia patients was 54.6% ,while was 12.6% in control group, there was a significant difference between two groups. There was a significant correlation between HDL - C and ED, only HDL - C was a protective factor of ED. There were positive correlation between ED and TC TG, on the contrary negative correlation between ED and HDL（ r = 0. 218, P 〈 0. 005） （ r = 0. 322, P 〈 0. 005 ） （ r = 0. 293, P 〈 0. 005 ） （ r = - 0. 467, P 〈 0. 005 ）, respectively. International index of erectile function -5 （IIEF -5 ） score can be improved by two ways of sexual function rehabilitation and changing lifestyle. Conclusion Dyslipidemia including high level of serum TC, high LDL,low HDL was related with ED, which was one of the main pathogenic factors of ED. ED can be treated by lipid -lowering therapy, sexual function rehabilitation and change lifestyle.