无痛人工流产中丙泊酚诱导量与体质量指数的相关分析

CORRELATION ANALYSIS OF THE INDUCED AMOUNT OF PROPOFOL AND THE BMI IN PAINLESS ABORTION

目的探讨无痛人流术时丙泊酚诱导量与患者体质量和体质量指数的相关性。方法选择自愿要求行无痛人工流产术的早孕妇女2 890例以100mg/min丙泊酚诱导,按体质量从轻到重每相差5kg为一组分为6组,体质量指数按照从小到大每相差2个指数为一组分为6组,分析患者意识消失时丙泊酚诱导量与体质量及体质量指数的关系。结果患者意识消失时的丙泊酚诱导量与体质量无相关性(r=0.42,P>0.05),但丙泊酚的诱导量与患者体质量指数有明显相关性,且随着体质量指数的增加而增加,组间比较差异有统计学意义(r=0.99,P<0.05)。结论丙泊酚诱导量与患者体质量不成比例,与体质量指数具有明显相关性,更适合指导临床用药。

Objective To investigate the correlation of the induced quantity of propofol with weight and body mass index （BMI） in painless abortion operation. Methods A total of 2890 pregnancy women who volunteered painless abortion were selected and induced by 100mg/min propofol. According to the body weight difference, from lighter to heavier, per more 5kg add a group, six groups were divided. At the same time, according to the BMI difference, from smaller to larger, per more 2BMI add a group, divided into six groups . The relationship between the quantity of propofol, body weight and BMI was analyzed. Results The quantity of propofol induction for consciousness loss had no correlation with weight, but had significant correlation with BMI, and with the increase of BMI, propofol increased, there were significant differences （ P 〈 0.05 ） between different groups. Conclusion The quantity of propofol induced is significantly correlated with BMI increasing, but not with body weight. This can guide the clinical use of drugs.