度洛西汀对抑郁症患者认知损害的汉语句子N400的影响

The effect of duloxetine on N400 of semantic matching at sentence--ending words in the treatment of depressive disorders

目的探讨度洛西汀对抑郁症患者汉语句子事件相关电位N400的影响。方法随机将年龄在18～60岁符合CCMD-3抑郁症诊断标准的60例患者分为阿米替林治疗组（实验组1，n=30）及度洛西汀治疗组（实验组2，n=30），选择30例健康者作为对照组。实验组治疗8周前后予汉密尔顿抑郁量表（HAMD）评分，各组分别予N400检测，分别比较N400潜伏期及波幅的差异。结果实验组1、实验组2Pz点潜伏期均比对照组延长，波幅均比对照组降低（P〈0．05及0．01）。治疗后，实验组1、实验组2FZ点潜伏期均比治疗前缩短，波幅均比治疗前升高（P〈0．05及0．01）。实验组2Pz点潜伏期比实验组1缩短，波幅均比实验组1升高（P〈0．05及0．01）。治疗后，实验组1HAMD评分高于实验组2（P〈0．01），实验组2显效率及总有效率明显高于实验组1（P〈0．01）。结论抑郁症患者存在与语言加工有关的认知损害，度洛西汀具有改善抑郁症患者认知功能的作用。

Objective To study the effects of treatment with Duloxetine on N400 of semantic matching of sentence--ending words in depressive disorders. Methods 60 patients （18~60 years old） met with CCMD--3 for depressive disorders criteria were divided into Amitriptyline treated group （research group 1）and Duloxetine treated group （research group 2） randomly. Both groups were assessed with HAMD and measured with N400 before and after 8 weeks treatment. 30 healthy individuals were selected as normal control group. N400 latencies and amplitudes of all groups were compared. Results N400 latencies prolonged and the amplitudes shortened in research group 1, 2 compared with normal control group （P 〈 0.05 or P 〈 0.01）. After treatment, N400 latencies reduced and the amplitudes hoisted in research group 1, 2 （P 〈 0.05 or P 〈 0.01） ; N400 latencies reduced and the amplitudes shortened in research group 2 compared with research group 1 （P 〈 0.05 or P 〈 0.01）. The HAMD scores of research group 1 are higher than research group 2 after treatment （P 〈 0.01）. Conclusions It presents cognitive dysfunction related semantic procession in depressive disorders, and the treatment with Duloxetine might improve cognitive dysfunction.