乌司他丁对脑出血患者急性期血清IL-1β和sICAM-1的影响

The influences of ulinastatin on serum levels of IL-1β and sICAM-1 in acute cerebral hemorrhage patients

目的观察乌司他丁对脑出血患者血清IL-1β和可溶性细胞间黏附分子水平的影响。方法对我院2006年7月～2010年7月神经内、外科的脑出血患者140例进行研究，随机分为对照组和治疗组两组，治疗组静滴乌司他丁14d，分别在入院第2，7，14天采用双抗体夹心ABC—ELISA法观察患者血清IL-1β和sICAM-1的水平。结果和对照组相比，乌司他丁可以降低脑出血患者急性期这两种炎性介质的水平，全部病例未出现明显副作用。结论乌司他丁可能可以作为抑制脑出血后炎性反应的备选药物之一。

Objective To investigate the influences of ulinastatin on serum levels of IL--1β （interleukin--1β） and sICAM- 1 （soluble intercellular adhesion molecule- 1）. Methods 140 cerebral hemorrhage patients were collected in 4 years （July in 2006 to July in 2010） from neurology and neurosurgery departments in the General Hospital of Chengdu Military Region were randomly divided into two groups： control group and treatment group. The treatment group was treated with ullnastatin 14 days i. v.. Blood samples were collected at three time points：day 2, day 7 and day 14 after admission to hospital. Serum levels of IL- 1β and sICAM- 1 were determined with double antibody ABC- ELISA. Results Compared with controls, the levels of two inflammatory mediators of cerebral hemorrhage patients in acute stage were significantly reduced by ulinastatin. All patients showed no obvious side effects. Conclusions The ulinastatin may be one of alternative medicines inhibiting the inflammatory response after intraeerebral hemorrhage.