PTTG1基因多态性rs2431697与汉族人寻常型银屑病表型的相关性研究

Correlation of rs2431697 polymorphism in PTTG1 gene with some clinical features of psoriasis vulgaris in Chinese Han population

目的探讨垂体瘤转化基因(PTTG1)基因多态性rs2431697与汉族人寻常型银屑病临床表型(有无家族史、发病年龄、皮损类型)的相关性。方法选取5 468例银屑病患者和6 406例正常对照的PTTG1基因多态性rs2431697的基因分型资料(基因分型采用Illumina 610芯片)。比较各组间等位基因和基因型频率的分布。结果 rs2431697等位基因和基因型频率分布在病例组和对照组间差异有显著性(P<1.0×10-3);有、无家族史患者间等位基因频率分布差异有显著性(P=0.02),而基因型频率分布差异无显著性;在少儿发病患者和成人发病患者,慢性斑块型患者和急性点滴型患者之间差异无显著性。结论 PTTG1基因多态性rs2431697与汉族人寻常型银屑病易感性有关,特别是与家族性银屑病相关性更为明显,但与发病年龄、皮损类型可能无关。

Objective To investigate the potential association between PTTG1 gene polymorphism rs2431697 and some phenotypes of psoriasis vulgaris including family history,the age of onset,lesions in Chinese Han population.Methods The genotyping data from genome-wide association study were analyzed in 5 468 cases and 6 406 controls for psoriasis,then compared the distribution of alleles and genotypes for rs2431697 in some clinical subgroups of psoriasis with Chi square test.Results The distribution of alleles and genotypes for rs2431697 were significantly different between cases and controls（P1.0×10-3）,and the distribution of alleles for rs2431697 was significantly different between familial cases and sporadic cases（P=0.02）.However,the difference between the pediatric onset psoriasis patients and the adult onset psoriasis patients,between the guttate and plaque cases did not show the statistical significance.Conclusion The results indicate that PTTG1 rs2431697 is associated with psoriasis susceptibility in Chinese Han population,especially for the family psoriasis,but may be not associated with age of onset and lesions type of psoriasis.