基质金属蛋白酶与肿瘤上皮间质转化的研究进展被引量：18

Matrix metalloproteinases and epithelial-mesenchymal transition in tumor:An advance

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摘要越来越多的研究表明,基质金属蛋白酶(matrix metalloproteinases,MMPs)与肿瘤细胞上皮间质转化(epithelial-mes-enchymal transition,EMT)的关系密切。MMPs是间质细胞表型的特有蛋白之一,既可以作为EMT发生的一个重要标志物,又可以诱发EMT。MMPs诱导肿瘤细胞发生EMT的机制是一个复杂的网络,可能涉及多个信号通路,如介导Rac1b激活ROS释放通路、活化TGF-β通路、降解E-cadherin促使β-catenin入核通路等。鉴于MMPs是诱导EMT促进肿瘤转移的一个关键因素,靶向MMPs已成为临床防治肿瘤的一个新策略。因此MMPs抑制剂则是当前研究热点,目前,多达50多种MMPs抑制剂被列入临床治疗肿瘤的候选药物,但其中大部分的疗效并未得到肯定。缺乏特异性则是其主要原因,故靶向MMP-EMT途径的肿瘤治疗仍然面临着很大的挑战,不仅需要鉴定出涉及肿瘤进展、促进EMT的主要或单一MMP,而且需要开发出具有高度特异性、选择性的MMPs抑制剂。

作者程先硕杨之斌殷正丰

机构地区云南省肿瘤医院大肠癌临床研究中心第二军医大学东方肝胆外科医院分子肿瘤实验室

出处《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2011年第4期437-440,共4页 Chinese Journal of Cancer Biotherapy

基金国家自然科学基金项目(No.30960455)~~

关键词基质金属蛋白酶上皮间质转化肿瘤转移

分类号 R730.2 [医药卫生—肿瘤]

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