摘要
糖基化终末产物(AGEs)是蛋白质和脂类经非酶糖基化后生成的含多种结构分子的混合物,阻断AGEs的致病途径有望成为改善糖尿病慢性并发症,缓解衰老,治疗老年痴呆等的新途径。该文主要综述了体内AGEs的来源,病理生理学机制,及AGEs生成抑制剂,断裂剂及AGEs受体阻断剂的研究进展。
Glycosylation end products (AGEs) are a mixture containing various structural compounds, which are products of proteins and lipids through non-enzymatic glycosylation. Bloc- king the pathogenesis of AGEs is expected to be an effective new way to improve the chronic complications of diabetes, to treat Alzheimer' s disease, and to ease aging. This article reviews the major source of AGEs in vivo, pathophysiological mechanisms,and the drug development of AGE-inhibitors, AGE-breakers and receptor antagonist agents of progress.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2011年第9期1185-1188,共4页
Chinese Pharmacological Bulletin
基金
中国科技部-魁北克合作项目(No2008DFA31710)
科技部十一五"重大新药创制"科技重大专项(No2009ZX09102-123)