糖基化终末产物及相关药物研究进展

Advanced glycosylation end products and related drug development

糖基化终末产物(AGEs)是蛋白质和脂类经非酶糖基化后生成的含多种结构分子的混合物,阻断AGEs的致病途径有望成为改善糖尿病慢性并发症,缓解衰老,治疗老年痴呆等的新途径。该文主要综述了体内AGEs的来源,病理生理学机制,及AGEs生成抑制剂,断裂剂及AGEs受体阻断剂的研究进展。

Glycosylation end products （AGEs） are a mixture containing various structural compounds, which are products of proteins and lipids through non-enzymatic glycosylation. Bloc- king the pathogenesis of AGEs is expected to be an effective new way to improve the chronic complications of diabetes, to treat Alzheimer＇ s disease, and to ease aging. This article reviews the major source of AGEs in vivo, pathophysiological mechanisms,and the drug development of AGE-inhibitors, AGE-breakers and receptor antagonist agents of progress.