摘要
目的:初步探讨Ⅳ型胶原蛋白(ColⅣ)、层黏连蛋白(LN)在鼻腔鼻窦恶性肿瘤中表达的相关性。方法:用免疫组织化学法检测137例鼻腔鼻窦恶性肿瘤、78例癌旁组织和37例对照组中ColⅣ和LN的表达。结果:ColⅣ和LN在鼻腔鼻窦恶性肿瘤、癌旁组织和对照组中的表达差异有统计学意义(P<0.01),在不同病理类型鼻腔鼻窦恶性肿瘤中的表达差异无统计学意义(P>0.05)。结论:ColⅣ和LN对鼻腔鼻窦恶性肿瘤的发生、发展起一定作用,在不同病理类型鼻腔鼻窦恶性肿瘤中可能发挥相似作用,无组织特异性。
Objective:To study the pathological relationship between the expression of ColⅣ and LN in nasal and paranasal sinus malignant tumor(NPMT).Method:The immunohistchemical technique was used to detected the expression of ColⅣ and LN in NPMT,para-cancer tissues and non-cancer tissues.Result:There was a significance on the expression of the ColⅣ and LN in NPMT,para-cancer tissues and non-cancer tissues(P0.01),and no significance in endepidermis and soft connective tissue of the NPMT(P0.05).Conclusion:The ColⅣ and LN perhaps participate in tumorigenesis of NPMT,and may play the homoioplastic role in different patholoigical types of the NPMT.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2011年第17期771-774,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
澳门科研基金委员会资助课题(No:029/2009/A)
广东省自然科学基金资助课题(No:9451063201003299)
关键词
Ⅳ型胶原蛋白
层黏连蛋白
细胞外基质
基膜
鼻窦肿瘤
ColⅣ
laminin
extracellular matrix
basal membrane
nasal and paranasal sinus malignant tumor
immunohistchemical stain