中药熏蒸治疗轻、中度寻常痤疮疗效观察及血清细胞因子水平检测

Clinical Observation of Chinese Herbal Fumigation for Minor or Medium Acne Vulgaris and Changes of Cytokines

目的评价中药熏蒸治疗轻、中度寻常痤疮的疗效,并探讨其作用机制。方法选取本科门诊的56例轻、中度寻常痤疮患者,随机分为两组,中药治疗组(28例,2例失访)予中药熏蒸,安慰剂组(28例,4例失访)予生理盐水熏蒸,26min/d,共治疗2周。评价两组患者的治疗效果,并检测39例患者治疗前、后血清中可溶性白介素-2受体(sIL-2R),白介素-4(IL-4),γ干扰素(IFN-γ)和白介素-8(IL-8)的水平变化。结果中药治疗组有效率为61.54%,安慰剂组为25.00%,两组比较差异有统计学意义(P<0.05)。中药治疗组患者治疗后血清sIL-2R,IL-4,IFN-γ和IL-8水平均较治疗前降低(P均<0.05)。安慰剂组治疗前后细胞因子水平无明显改变(P均>0.05)。结论中药熏蒸治疗轻、中度寻常痤疮有效,其作用机制可能与其对细胞免疫和体液免疫的调节作用有关。

Objective To evaluate the clinical efficacy of Chinese herbal fumigation in treating Acne Vulgaris and to ex- plore its machanism. Methods A total of 56 cases were randomly divided into two groups. Patients in the treatment group （ n = 28） were treated with Chinese herbal fumigation （2 cases lost ）. Patients in the placebo group（ n = 28） were treated with fumigation using saline water （4 eases lost ）. The clinical efficacy and the changes of serum level of soluble interleukin-2 recepter （ slL-2R）, interleukin-4 （ IL-4 ）, interferon-γ/（IFN-3,）, interleukin-8 （IL-8） in 39 patients were assayed after 2 weeks. Results The clinical efficacy of the treatment group was 61.54% , and it was 25.00% in placebo group. There was sighifieant difference between two groups （ P 〈 0.05 ）. The level of sIL-2R , IL-4, IFN-γ/and IL-8 reduced significantly after the treatment （ P 〈 0.05 ） in the treatment group. The level of slL-2R, IL-4, IFN-3, and IL-8 in the placebo group showed no significant change （P 〉 0.05 ）. Conclusion The Chinese herbal fumigation is effective in treatment of minor or medium degree of acne and its mechanism may be related with its modulation of both cell-mediated immunity and hu- moral immunity.