miRNA在造血调控和骨髓增殖性肿瘤中作用的研究进展

Advance of Studies on Role of miRNA in Hematopoietic Regulation and Myeloproliferative Neoplasms——Review

microRNA(miRNA)是一类广泛存在于各种真核生物中大小约为19-25个碱基的单链非编码小分子RNA。miRNA在转录后水平通过促进靶mRNAs的降解或抑制其翻译过程而发挥负调控的作用。已有研究表明,miRNA能参与造血调控,进而与血液系统疾病的发生存在密切的关系。本文就近年来miRNA在血液细胞分化调控中的作用及其与骨髓增殖性肿瘤的发生、发展关系,诸如miRNA与淋巴细胞生成,miRNA与红细胞生成,miRNA与巨核细胞形成,miRNA与粒细胞形成,miRNA与BCL-ABL阳性的骨髓增殖性肿瘤-慢性髓系白血病,miRNA与BCR-ABL阴性的MPN(PV.IMF,ET)等相关研究作一综述。

microRNA （miRNA） are small non-coding RNA molecules of 19 -25 nucleotides in a variety of eukaryotic systems, that control gene expression at the post-transcriptional level by degrading or translational repressing target messenger RNA （mRNA）. Many studies have addressed the role of miRNA in normal hematopoiesis, giving an interpretative key to the aberrant expression observed in human hematological diseases. Here, the advances of main studies on the role of miRNA in normal hematopoiesis, and identify the association of miRNA with the development, progression of myeloproliferative diseases, including miRNA and lymphopoiesis, miRNA and erythropoiesis, miRNA and megakaryopoiesis, miRNA and myelopoiesis, miRNA and myeloproliferative neoplasm with positive BCR-ABL-chronic myeloid leukemia, miRNA and myeloproliferative neoplasm with negative PCR-ABL （PV. IME, ET）, and so on are reviewed.