不同负荷跑台运动对雌性大鼠骨骼的作用及其位点效应

Function and site-effect of different load treadmill exercises on bones of female rats

背景:活体骨骼在力学环境发生变化时,骨的建造和重建发生力学适应性变化。而不同强度运动对骨骼的作用以及对不同部位骨骼的适应性变化尚不明确。目的:探讨不同负荷跑台运动对雌性大鼠不同部位骨骼骨密度的影响及其位点效应。方法:雌性SD大鼠随机分为运动组和对照组,运动组进行为期17周的跑台训练,测量运动第4,7,9,11,13,15,17周时两组大鼠全身、颅骨、前肢、肋骨、脊椎骨、盆骨、后肢的骨密度。结果与结论:运动对于大鼠全身、颅骨、前肢骨、脊椎和盆骨的骨密度具有较大影响,而对于肋骨的骨密度的影响没有显著性意义,说明跑台运动对大鼠不同部位骨骼的作用不同。

BACKGROUND：The bone modeling and bone remodeling will have an adapted change when the situation of mechanics changed in vivo bone. But it is not very certain what the adapted change is when different training load exerted to the bone. OBJECTIVE：To explore the influence and site-effect of different load treadmill exercises on female rat’s various bone mineral density （BMD）. METHODS：Female Sprague-Dawley rats were randomly divided into training group and control group. Training group received treadmill training for 17 weeks. The BMD of whole bodies, skulls, forelimbs, ribs, spines, pelvises, and hind limbs were tested at 4, 7, 9, 11, 13, 15 and 17 weeks after training. RESULTS AND CONCLUSION：Exercise has great effects on BMD of whole bodies, skulls, forelimbs, spines, and pelvises, but does not affect the BMD of ribs. These suggest that treadmill training has different effects on bones at different parts of rats.