血液透析膜材料在重症胰腺炎领域的应用

Hemodialysis membrane materials for severe acute pancreatitis

背景:透析膜材料是影响血液透析治疗效果的关键因素。目的:评价血液透析膜材料在重症胰腺炎领域的应用及生物相容性,为其在临床上的应用提供参考依据。方法:以"血液透析;透析膜材料;组织相容性;血液相容性;聚醚砜"为中文关键词;以"hemodialysis,dialysismembranematerials;histocompatibility;bloodcompatibility;polyethersulfone"为英文关键词,采用计算机检索1994-06/2011-02相关文章。纳入与有关生物材料与宿主相容性的文章;排除重复研究或Meta分析类文章。以25篇文献为重点进行探讨聚砜膜滤器材料的性能及应用前景。结果与结论:同时连续性血液净化对多器官功能障碍综合征疗效确切,尤其对出现急性肾功能不全的患者疗效尤为显著,因此可最终改善重症急性胰腺炎患者预后,成为目前治疗重症急性胰腺炎的重要手段。血液透析膜的类型较多,聚砜膜滤器应用广泛,其宿主生物相容性较好,封堵效果也较好,因费用较低,临床广泛应用。

BACKGROUND： Dialysis membrane materials are the key factor influencing clinical outcome of hemodialysis. OBJECTIVE： To assess the biocompatibility of hemodialysis membrane materials for severe acute pancreatitis. METHODS： A computer retrieval of articles published 1994-06/2011-02 was performed using the Keywords of ＂hemodialysis, dialysis membrane materials, histocompatibility, blood compatibility, polyethersulfone＂ in Chinese and English. Repetitive studies or Meta analysis were excluded, and finally 25 articles addressing performance and application of polyethersulfone membrane filtering material were included. RESULTS AND CONCLUSION： Continuous blood purification has a certain effect on multiple organ dysfunction syndrome, especially on acute renal failure. As a result, it can improve the prognosis of severe acute pancreatitis and becomes an important treatment for severe acute pancreatitis. Hemodialysis membranes are various. Polyethersulfone membrane filters are widely used, which have a good biocompatibility with the host. The sealing effect is good, and due to lower cost, it is widely used in clinic.