左炔诺孕酮宫内缓释系统在妇科疾病治疗中的作用

Effects of levonorgestrel-releasing intrauterine system in treating gynecological diseases

背景:左炔诺孕酮宫内缓释系统有很高的避孕可靠性,可对子宫内膜产生明显的抑制作用。目的:阐述左炔诺孕酮宫内缓释系统在妇科疾病治疗中的作用。方法:由第一作者检索CBM、PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)、万方数据库(http://wwwwanfangdata.com.cn)及google学术网1990/2010有关左炔诺孕酮宫内缓释系统治疗妇科疾病的文献,排除重复性研究。结果与结论:共保留17篇文献进行归纳总结。结果显示,左炔诺孕酮宫内缓释系统作为释放微量孕激素的宫内缓释系统,可安全、有效地应用于避孕,治疗月经过多、内异症、子宫腺肌病,以及激素替代治疗中对子宫内膜的保护等,对治疗子宫肌瘤引起的月经过多也有良好效果。提示左炔诺孕酮宫内缓释系统治疗妇科疾病效果显著,但还需要大样本、长期的临床研究加以验证。

BACKGROUND： Levonorgestrel-releasing intrauterine system is reliable in contraception by inhibiting endometrium. OBJECTIVE： To elucidate effects of levonorgestrel-releasing intrauterine system in treating gynecological diseases. METHODS： A computer-based online search of CBM, PubMed database （http：//www.ncbi.nlm.nih.gov/PubMed）, Wanfang database （http：//www.wanfangdata.com.cn）, and google search was performed for articles related to levonorgestrel-releasing intrauterine system in treating gynecological diseases, published between 1990 and 2010. Repetitive studies were excluded. RESULTS AND CONCLUSION： A total of 17 articles were included. As intrauterine progestogen-releasing system, levonorgestrel-releasing intrauterine system can be used as a safe and effective contraception method. In addition, it can treat menorrhagia, endometriosis, adenomyosis, protect endometrium, and ameliorate hysteromyoma-induced menorrhagia. Results revealed that levonorgestrel-releasing intrauterine system can effectively treat gynecological diseases. However, large-sample, long-term clinical studies are required.