期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

首发和慢性精神分裂症脑白质的弥散张量成像 被引量：9

Diffusion tensor imaging findings in first-episode and chronic schizophrenics
原文传递
导出
摘要 目的分析首发精神分裂症和慢性精神分裂症脑白质完整性变化。方法2009年8月至2011年2月在中山大学附属第三医院精神科住院部或门诊部就诊的39例首发精神分裂症患者、38例慢性精神分裂症患者和广告招募的69名健康对照进行脑磁共振弥散张量成像，3组图像以基于体素的分析方法进行单因素方差分析，提取阳性结果区平均FA值再进行多重比较。结果（1）首发精神分裂症、慢性精神分裂症和健康对照在以下脑区的白质FA值存在差异：右侧尾状核区域（MNI：20、12、14，cluster=432voxels，FA值：0．36±4-0．18比0．35±0．24比0．38±0．17）；左侧岛叶区域（MNI：-32、18、2，cluster=204 voxels，FA值：0．35士0．31比0．33±0．24比0．36±0．21）；右侧前扣带区（MNI：16、36、12，cluster=132voxels，FA值：0．35±0．29比0．34±0．31比0．37±0．25）。（2）两患者组上述脑区的白质平均FA值均低于健康对照组（均P〈0．05）。（3）慢性精神分裂症左侧岛叶区的白质平均FA值低于首发精神分裂症（P〈0．05），另两脑区FA值两组间差异无统计学意义。结论脑白质完整性异常与精神分裂症的发病机制可能有关，且可能进行性发展。 Objective To investigate the integrity of white matters in first-episode and chronic schizophrenics. Methods For this study, 39 first-episode and 38 chronic schizophrenics, 69 healthy controls （age, gender and years of received education no significantly different from those of the patients） underwent diffusion weighted images with a single-shot echo planar imaging （EPI） sequence aligned to the straight axial plane. The fractional anisotropy （FA） images of three groups underwent one-way ANOVA with the methods of voxel-based morphometric （ VBM ） analysis. Results （ 1 ） There were three brain regions where the FA values of white matter were different among three groups ： fight caudate nucleus （ MN1：20, 12, 14; cluster =432 voxels; FA value：O. 36±0. 18 vs O. 35±0. 24 vs 0. 38 ±0. 17）, left insula （MNI： -32, 18, 2; cluster = 204 voxels; FA value：0. 35± 0. 31 vs O. 33 ＋ O. 24 vs O. 36 ± 0. 21 ） and right anterior cingulated（MNI：16, 36, 12; cluster = 132 voxels;FA value：0. 35±0. 29 vs 0. 34±0. 31 vs 0.37±0. 25）. （2） The mean FA values of the three brain regions of two patients groups decreased versus those of healthy controls （ P 〈 0. 05 ）. （ 3 ） The mean FA values of left insular region in chronic patients decreased versus those of the first-episode patients （ P 〈 O. 05 ）. Conclusion The reduced integrity of white matter may play an etiological role in schizophrenia and the changes are probably progressive.
作者 魏钦令 康庄 吴小立 张晋碚 李雷俊 郑俩荣 国效峰 赵靖平
机构地区 中山大学附属第三医院精神科 中山大学附属第三医院精神科 中山大学附属第三医院放射科 精神科
出处 《中华医学杂志》 CAS CSCD 北大核心 2011年第31期2186-2189,共4页 National Medical Journal of China
基金 国家自然科学基金（81071093） 国家自然科学基金其青年项目（30900485） 2010年卫生行业科研专项（201002003）
关键词 精神分裂症 磁共振成像 弥散 脑白质 Schizophrenia Diffusion magnetic resonance imaging White matter
分类号 R749.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

  • 1Pettersson-Yeo W, Mlen P, Benetti S, et al. Dysconnectivity in schizophrenia : Where are we now? Neumsci Biobehav Rev, 2011, 35:1110-1124.
  • 2Begre S, Koenig T. Cerebral disconnectivity: an early event in schizophrenia. Neuroscientist ,2008,14 : 19-45.
  • 3Waherfang M, Wood SJ, Velakoulis D, et al. Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia. Neurosci Biobehav Rev,2006 ,30 :918-948.
  • 4Agarwal N, Port JD, Bazzocchi M, et al. Update on the use of MR for assessment and diagnosis of psychiatric diseases. Radiology,2010,255:23-41.
  • 5Ramnani N, Behrens TE, Penny W, et al. New approaches for exploring anatomical and functional connectivity in the human brain. Biol Psychiatry ,2004,56:613-619.
  • 6Konrad A, Winterer G. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? Schizophr Bull ,2008,34:72-92.
  • 7魏钦令,康庄,王相兰,张晋碚,李雷俊,郑俩荣,韩自力.首发未服药偏执型分裂症脑白质的弥散张量成像研究[J].中华行为医学与脑科学杂志,2010,19(9):784-786. 被引量：8
  • 8Kong X, Ouyang X, Tao H, et al. Complementary diffusion tensor imaging study of the corpus callosum in patients with first- episode and chronic schizophrenia. J Psychiatry Neurosci, 2011, 36 : 120-125.
  • 9Friedman JI, Tang C, Carpenter D, et al. Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients. Am J Psychiatry,2008,165 : 1024-1032.
  • 10司天梅,杨建中,舒良,王希林,孔庆梅,周沫,李雪霓,刘粹.阳性和阴性症状量表(PANSS,中文版)的信、效度研究[J].中国心理卫生杂志,2004,18(1):45-47. 被引量：657

二级参考文献38

  • 1Pantoni L, Poggesi A, Inzitari D. The relation between whitematter lesions and cognition. Curr Opin Neurol, 2007,20: 390- 397.
  • 2Ble A, Ranzini M, Zurlo A, et al. Leukoaraiosis is associated with functional impairment in older patients with Alzheimer's disease but not vascular dementia. J Nutr Health Aging, 2006, 10 : 31-35.
  • 3Mantyla R, Aronen H J, Salonen O, et al. The prevalence and distribution of white matter changes on different MRI pulse sequences in a poststroke cohort. Neuroradiology, 1999, 41 : 657-665.
  • 4Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch Neurol, 1987, 44:21-23.
  • 5O'Brien JT, Erkinjuntti T, Reisberg B, et al. Vascular cognitive impairment. Lancet Neurol, 2003,2:89-98.
  • 6Foong J, Maier M, Clark CA, et al. Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. J Neural Neurosurg Psychiatry, 2000, 68: 242-244.
  • 7Pantoni L, Garcia JH. Pathogenesis of leukoarasis: a review. Stroke ,1997. 28:652-659.
  • 8Van Gijin J. Leukoarasis and vascular dementia. Neurology, 1998, 51: $3-8.
  • 9Baloh RW, Yue Q, Socotch TM, et al. White matter lesions and disequilibrium in older people. I. Case-control comparison. Arch Neurol , 1995, 52:970-974.
  • 10O'Sullivan M, Summers PE, Jones DK, et al. Normal appearing white matter in ischemic leukoaraiosis: a diffusion tensor MRI study. Neurology , 2001, 57:2307-2310.

共引文献680

同被引文献146

  • 1Insel TR. Rethinking schizophrenia. Nature,2010,468 : 187-193.
  • 2Gejman PV, Sanders AR, Duan J. The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am,2010,33:35- 66.
  • 3Kaymaz N, van Os J. Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia. Int Rev Neurobiol, 2009,89 : 85 -130.
  • 4Lawrie SM, Mcintosh AM, Hall J, et al. Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk. Schizophr Bull,2008,34 : 330 -340.
  • 5Pettersson-Yeo W, Alien P, Benetti S, et al. Dysconnectivity in schizophrenia : where are we now? Neurosci Biobehav Rev, 2011, 35:1110-1124.
  • 6Munoz MS, Lymer GK, Bastin ME, et al. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophr Res ,2008,106 : 132-139.
  • 7Hoptman M J, Nierenberg J, Bertisch HC, et al. A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr Res ,2008,106 : 115-124.
  • 8Camcbong J, Lim KO, Sponheim SR, et al. Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients' nonpsychotic relatives. Front Hum Neurosci ,2009,3:35.
  • 9Hao Y, Yan Q, Liu H, et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophr Res,2009,114 : 128-135.
  • 10Kim SN, Park JS, Jang JH, et al. Increased white matter integrity in the corpus callosum in subjects with high genetic loading for schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry,2012, 37:50-55.

引证文献9

二级引证文献37

中华医学杂志
2011年 第31期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部