ARHI蛋白在宫颈腺癌病因学中的意义研究

Significance of ARHI protein in adenocarcinoma of the uterine cervix

目的检测ARHI蛋白在宫颈腺癌组织及正常宫颈腺体组织中的表达情况，探讨其在宫颈腺癌发病机制中的作用。方法采用免疫组织化学法检测ARHI蛋白在30例宫颈腺癌组织和30例正常宫颈腺体组织中的表达情况，分析ARHI蛋白的表达与宫颈腺癌发生的关系。结果宫颈腺癌组织中ARHI蛋白阳性表达率[46．67％（14／30）]低于正常宫颈腺体组织[90．00％（27130）]（P〈0．05）。ARHI蛋白与宫颈腺癌组织学分级、FIGO分期密切相关（P〈0．05），与淋巴结转移无相关性（P〉0．05）。结论ARHI蛋白在宫颈腺癌组织中表达降低，证明ARHI抑癌基因在宫颈腺癌组织中的表达降低可能与宫颈腺癌的发生有关，ARHI蛋白可作为宫颈腺癌病因学的一个新指标。

Objective To detect the expression of ARHI protein in adenocarcinoma of the uterine cervix and normal uterine cervix tissue, and explore the pathogenesis of cervical cancer. Methods The expression of ARHI protein in 30 cases of adenocarcinoma of the uterine cervix tissue and 30 cases of normal uterine cervix tissue was detected by immunohistochemistry and analyzed the relationship between ARHI protein and adenocarcinoma of the uterine cervix. Results The expression of ARHI protein in adenocarcinoma of the uterine cervix tissue [46.67%（14/30） ] was lower than that in normal uterine cervix tissue[90.00% （27/30） ], the difference was significant （P 〈 0.05）. There was intimate correlation between ARHI protein and histological grade, FIGO stage of adenocarcinoma of the uterine cervix tissue （P 〈 0.05 ）, there was no correlation between ARHI protein and lymphatic metastasis （P 〉 0.05 ）. Conclusions The expression of ARHI protein in adenocarcinoma of the uterine cervix decreases which indicates the expression of ARHI protein take part in the carcinogenesis of adenocarcinoma of the uterine cervix. It can be used as a new diagnostic indicator of adenocarcinoma of the uterine cervix.