nm23和VEGF-C在胃癌组织中的表达及意义

Expression and clinical significance of nm23,VEGF-C in gastric carcinoma tissues

目的探讨nm23及血管内皮生长因子-C(VEGF-C)表达与胃癌的生物学行为及淋巴结转移的关系。方法应用免疫组化法对52例胃癌组织中nm23及VEGF-C表达进行测定。结果 nm23低表达或VEGF-C高表达者淋巴结转移率明显高于无淋巴结转移组(P<0.05),而与肿瘤大小、TNM、性别无关(P>0.05)。结论通过nm23及VEGF-C表达检测对估计肿瘤转移预后有显著意义,而且二者协同检测意义更大。

Objective To investigate the correlation between the expression of nm23, vascular endothelium growth factor-C （VEGF-C） and biological behavior as well as lymphatic metastasis of gastric carcinoma tissues. Methods The immunohistochemical method was used to detect the expression of VEGF-C and nm23 in 52 cases of gastric carcinoma tissues. Results The lymphatic metastasis rate in low-expression of nm23 or high-expression of VEGF-C of gastric carcinoma tissues was significantly higher than that without lymphatic metastasis tissues （ P 〈 0.05 ）, however, which was not related with the size of carcinoma, TNM and patients＇ sex （ P 〉 0.05 ）. Conclusion The detection of nm23 and VEGF-C expression levels plays an important role in evaluating patients＇ prognosis and carcinoma metastasis, furthermore, the combined detection of nm23 with VEGF-C has more significant clinical value.