血清CA125、CA19-9联合监测在盆腔肿物鉴别诊断中的价值

The Value of Combine Detection of Serum Levels of CA125 and CA19-9 on the Differential Diagnosis of the Pelvic Cyst

探讨血清CA125、CA19-9水平在盆腔肿物鉴别诊断中的价值。对我院2008年1月至2009年12月因盆腔肿物住院的166例患者的术前血清CA125、CA19-9水平进行回顾性分析;按照病理类型分为4组,分别为卵巢良性肿瘤组、卵巢子宫内膜异位囊肿组、盆腔炎性肿物组、卵巢恶性肿瘤组。结果显示:卵巢恶性肿瘤组血清CA125水平明显升高,与其他组比较,有显著差异(P<0.05);血清CA19-9水平比较,差异无统计学意义(P>0.05)。卵巢子宫内膜异位囊肿组血清CA125水平明显高于卵巢良性肿瘤组,有显著差异(P<0.05),与盆腔炎性肿物组比较,尽管平均值较高,但无统计学差异(P>0.05);而血清CA19-9水平升高,与盆腔炎肿物组比较有显著差异(P<0.05)。血清CA125、CA19-9的测定对于鉴别卵巢良恶性肿瘤有明确诊断价值;两项联合检测优于单项检测;两项联合对于卵巢良性肿物、炎性病变、卵巢子宫内膜异位囊肿有鉴别意义,依据CA125、CA19-9水平可以大致推测肿物性质。

To investigate the value of detection of serum levels of CA125 and CA19-9 on the differential diagnosis of the pelvic cyst,the serum levels of CA125 and CA19-9 in 166 patients with pelvic tumor were retrospectively analyzed.The patients were divided into four groups according to the pathological type： ovarian benign cyst group（except for ovarian endometriosis cyst）;ovarian endometriosis cyst group;inflammatory lesion group and ovarian carcinoma group.The results showed that the serum CA125 level in ovarian carcinoma group compared with other groups was increased dramatically（P0.05）,but no significantly difference on serum CA19-9（P0.05）.The serum CA125 levels in patients with ovarian endometriosis cyst were higher than that of ovarian benign cyst group（P0.05）.The serum CA19-9 levels in patients with ovarian endometriosis cyst compared with inflammatory lesion group were increased（P0.05）.Conclusion The combined detection of serum CA 125 and CA 19-9 has clear clinical value in the differential diagnosis of the benign cyst and carcinoma.