摘要
大量研究表明,慢性心功能衰竭[1],右向左分流先天性心脏病[2],和阻塞性肺病[3]等机体存在低氧状况时血尿酸水平增高,血尿酸水平已被证明是慢性心力衰竭病人远期死亡的独立危险因素[4]。
Objective To investigate the relationship between Uric Acid（UA） level and the severity of Idiopathic Pulmonary Artery Hypertension（IPAH）.Methods 67 patients with IPAH had a measurement of UA and an assessment of NYHA,then the right heart catheterization were carried out on the patients.The relations between UA and Laboratory results,UA and hemodynamic parameters,UA and NYHA class were assessed.The treatment group of 30 healthy volunteers are compared with the control subjects.Results UA increased significantly in patients with IPAH as compared by control subjects（405.21±130.12μmol/L versus 344.02±96.12μmol/L,P0.05）.Serum UA correlated positively with mean pulmonary artery pressure and total pulmonary vascular resistance（r=0.55,P0.01）,and correlated negatively with cardiac output index（r=-0.28,P0.05）.UA was 348.02±70.31μmol/L in NYHA class Ⅱ,416.02±126.27μmol/L in NYHA class Ⅲ,and610.33±147.41μmol/L in NYHA class Ⅳ（P0.05 between class Ⅱ and Ⅲ,P0.01 between class Ⅲ and Ⅳ）.UA had a positive correlation of medium intensity with NYHA class（r=0.41,P=0.01）.Conclusions UA increases in patients with IPAH and it could reflect the disease severity.
出处
《心脑血管病防治》
2011年第4期259-260,266,I0001,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
