急性白血病患者化疗前后血清IGF-Ⅱ、TNF-α和TSGF检测的临床意义

Clinical Significance of Estimation of Changes in Serum IGF-Ⅱ,TNF-α and TSGF Levels After Chemotherapy in Patients with Acute Leukemia

目的:探讨了急性白血病患者化疗前后血清IGF-Ⅱ、TNF-α和TSGF水平的变化及临床意义。方法:应用放射免疫分析和生化法对33例急性白血病患者进行了治疗前后血清IGF-Ⅱ、TNF-α和TSGF检测,并与35例正常健康人作比较。结果:急性白血病患者治疗前血清IGF-Ⅱ、TNF-α和TSGF水平均非常显著地高于正常人组(P<0.01),化疗后6个月未复发者28例中明显下降接近正常人组,而复发的5例其数值又回升到化疗前水平(P<0.05)。结论:检测急性白血病患者血清IGF-Ⅱ、TNF-α和TSGF水平的变化可作为诊断和疗效观察的指示性参数。

Objective To explore the clinical significance of changes in serum IGF-Ⅱ,TNF-α and TSGF levels after chemotherapy in patients with acute leukemia.Methods Serum IGF-Ⅱ,TNF-α（with RIA） and TSGF（with biochemistry） levels were determined in 33 patients with acute leukemia both before and after chemotherapy as well as in 35 normal healthy Controls.Results Before chemotherapy,serum IGF-Ⅱ,TNF-α and TSGF levels in the patients were significantly higher than those in controls（P0.01）,6 months after chemotherapy the levels in 28 patients without recurrence dropped markedlly and approached those in controls.However,in the 5 eases with recurrence,the levels after return again,approaching those before chemotherapy.Conclusion Changes of serum levels on IGF-Ⅱ,TNF-α and TSGF might be useful as indicative parameters for diagnosis and curative effect in patients with acute leukemia.