男性不育症患者血清TNF-α、T、FSH、PRL检测的临床意义

Clinical Significance of Measurement of Serum TNF-α,T,FSH and PRL Levels in Male Infertility

目的:探讨男性不育症患者血清TNF-α、T、FSH、PRL水平的变化及临床意义。方法:应用放射免疫分析对36例男性不育症患者进行了血清TNF-α、T、FSH、PRL检测,并与35例男性正常人作比较。结果:男性不育症患者血清T水平非常显著地低于男性正常人组(P<0.01),而TNFα-、FSH、PRL水平又非常显著地高于男性正常人组(P<0.01),血清TNF-α水平与T水平呈负相关(r=-0.5184,P<0.01),与FSH、PRL水平呈正相关(r=0.6184、0.5925,P<0.01)。结论:检测男性不育症患者血清TNF-α、T、FSH、PRL水平的变化对诊断、预后判断及治疗均有较大的临床价值。

Objective To explore the significance of changes of serum TNF-α,T,FSH and PRL levels in male patients with infertility.Methods Serum TNF-α,T,FSH and PRL（with RIA） were measured in 36 male patients with infertility and 35 male controls.Results Serum T level was significantly lower in the patients than those in controls（P0.01）,while the serum TNF-α,FSH and PRL levels were significantly higher in the patients（P0.01）.Serum TNF-α level was negatively correlated with T level in the patients（r=-0.5184,P0.01） and positively correlated with FSH,PRL levels（r=0.6184,0.5925,P0.01）.Conclusion Serum TNF-α,T,FSH and PRL levels were significantly changed in male with infertility and determination of which might useful for prognosis and treatment clinically.