HE4与CA125联检在卵巢恶性肿瘤诊断中的价值

Significance of Serum Human Epididymis Secretory Protein 4 and CA125 Assay in the Diagnosis of Ovarian Malignancy

目的:探讨人血清附睾蛋白4(HE4)和CA125在卵巢恶性肿瘤诊断中的价值。方法:检测卵巢恶性病变组(n=116)和良性病变组(n=92)女性患者血清HE4、CA125的水平;并与48例体检健康妇女(正常对照组)相比较。结果:在卵巢恶性病变组中,HE4、CA125的水平显著高于良性病变组和正常对照组(P<0.05);HE4与CA125联检诊断卵巢癌的灵敏度为88.8%,阴性预测值83.3%,准确率为80.8%,均显著高于HE4、CA125各单项检测值(P<0.05)。结论:联检HE4与CA125,可提高诊断卵巢癌灵敏度。

Objective To investigate the vlaue of detection of human epididymis secretory protein 4（HE4） and CA125 in the diagnosis of ovarian malignancy.Methods Serum HE4 levels were measured by enzyme-linked immunosorbent assay（ELISA） and serum CA125 concentrations were determined by chemiluminescent immunoassay（CLIA） in ovarian cancer patients（n=116）,benign ovarian disease patients（n=92） and healthy controls（n=48）.Results Serum HE4 levels and CA125 concentrations in ovarian cancer patients were significantly higher than those in bengin ovarian disease patients and healthy controls（P0.05） respectively.The sensitivity,negative predict value and accuracy of the dual marker combination of HE4 and CA125 were higher than those in of HE4 and CA125 alone（P0.05）,which were 88.8%,83.8% and 80.8%,individually.Conclusion The combination of CA125 and HE4 might be a suitable synergy to improve the diagnosis of ovarian cancer.