血清-βCTX和Total-P1NP联检在前列腺癌骨转移监测中的价值

Significance of the β-CTX and P1NP Combined Detection in the Diagnose of Osseous Metastasis of Prostatic Carcinoma

目的:为探讨血清Ⅰ型胶原羧基端肽β特殊序列(-βCTX)和总Ⅰ型胶原氨基端延长肽(Total-P1NP)在前列腺癌骨转移监测中的意义。方法:用电化学发光免疫分析检测血清β-CTX和Total-P1NP水平。结果:发现前列腺癌骨转移组的血清β-CTX明显高于无骨转移组及正常对照组(P均<0.05),而血清Total-P1NP明显低于无骨转移组及正常对照组(P均<0.05)。结论:检测血清β-CTX和Total-P1NP对前列腺癌患者骨转移的及时诊断有重要的参考意义。

Objective To investigate the significance of serum c-terminal cross-linking telopeptide of type Ⅰ collagen（β-CTX） and total type I procollagen N-terminal peptide（P1NP） detections in monitoring osseous metastasis of prostatic carcinoma.Methods The levels of serum β-CTX and P1NP were detected by electrochemical immunoassay.Results Serum β-CTX levels of osseous metastasis of prostatic carcinoma group were significantly higher than those in the group of prostatic carcinoma alone and the control group（P0.05）.Conversely,serum P1NP levels of osseous metastasis of prostatic carcinoma group were significantly lower than those in the group of prostatic carcinoma alone and the control group（P0.05）.Conclusion Significance of the β-CTX and P1NP detection in the diagnose of osseous metastasis of prostatic carcinoma in time should be noted.