女性肥胖不孕症患者治疗前后血浆瘦素和血清胰岛素、睾酮、水平检测的临床意义

Clinical significance of changes of plasma leptin and serum insulin / testosterone levels before and after treatment in patients with woman obesity of infertile

目的探讨女性肥胖不孕症患者治疗前后血浆瘦素(Leptin)和血清胰岛素(Ins)、睾酮(T)水平的变化及临床意义。方法应用放射免疫分析法对31例女性肥胖不孕症患者进行了治疗前后血浆Leptin和血清胰岛素、睾酮水平的检测,并与35名正常女性作比较。结果女性肥胖不孕症患者在治疗前血浆Leptin和血清胰岛素、睾酮水平非常显著地高于正常人组(P<0.01),经药物治疗6个月后与正常人比较差异仍有显著性(P<0.05),且血浆Leptin水平与血清胰岛素和睾酮水平呈正相关(r值分别为0.6012、0.4984,P值均小于0.01)。结论检测女性肥胖不孕患者治疗前后血浆Leptin和血清胰岛素、睾酮水平的变化对了解病情、观察治疗均具有重要的临床价值。

Objective To explore the significance of changes of plasma leptin and serum insulin/testosterone levels before and after treatment in patients with woman obesity of infertile.Methods Plasma leptin and serum insulin / testosterone levels were measured with RIA in 31 patients with woman obesity of infertile both before and after treatment as well as in 35 controls.Results Before treatment,plasma leptin and serum insulin / testosterone levels were significantly higher than those in the controls（P0.01）.Six months after treatment,plasma leptin and serum insulin / testosterone levels had significance（P0.05）.The plasma leptin levels were positively correlated with insulin / testosterone（r=0.6012,0.4984,P0.01）.Conclusion Detection of plasma leptin and serum insulin / testosterone levels is valuable for the treatment outcome prediction in patients with woman obesity of infertile.