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糖原合酶激酶3与2型糖尿病的关系 被引量：2

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摘要 糖原合成酶激酶3（glycogen synthase kinase 3,GSK3）于1980年被鉴定出来后[1],一度被认为仅仅是一个调节糖原代谢的蛋白激酶。其后,研究证实GSK3在多种细胞功能活动的调节中扮演着重要的角色。包括调节细胞的结构、细胞内的信号传导、细胞的分裂、凋亡、微管运动。
作者 伍松（综述） 汤礼军（审校）
机构地区 成都军区总医院全军普外中心
出处 《西南军医》 2011年第5期911-913,共3页 Journal of Military Surgeon in Southwest China
关键词 糖原合酶激酶3 糖原合酶激酶3抑制剂 2型糖尿病
分类号 R587.1 [医药卫生—内分泌]
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参考文献17

  • 1EMBIN, RYLATTDB, COHENP, et al. Glycogen synthase kinase.2 - 3 from rabbit skeletal muscle; scparati on from cyclic2 AMP - de- pend -ent p r otein kinase and phos phorylase kinase [J]. Eur J Bi ochem,1980, 107:5192 5271.
  • 2Liu, Y. et al. Conditional ablation of Gsk -3beta in islet beta cells results in expanded mass and resistance to fat feeding - induced dia- betes in mice [J]. Diabetologia. 2010 Dec;53(12) :2600 -2610.
  • 3AOKIM, Y OKOTA T, SUGI URA I , et al. Structural insight int onucleotide recogniti on in tau- protein kinase I/glycogen syn- thasekinase 3 beta [J]. Acta Crystallogr D Bi ol Crystall ogr, 2004, 60(Pt3) : 43924461.
  • 4Bhat R V, Shanley J, CorrellM P, et aL Regulation and localizati on of tyro.sine 216 phos phorylation of glycogen synthase kinase2 3beta in cellular and artimal modeh of neur onal degenerati on [JJ. ProcN atl Acad Sci USA , 2000, 97 (20) : 11074-11079.
  • 5MIK, DOLANP J, JOHNSONG V,et al . The low density lipop mtdnrecep t orrelated p r otein 6 interactswith.
  • 6Frame S, Cohen P. GSK3 takes cent re st age m ore than 20 yearsaf t er it s discovery [ J] . Biochem J, 2001, 359:1 16.
  • 7Nikoulina SE , ciaraldi TP , Mudaliar S, et, al, Molecular mechanism for the synergistic action of casein kinase Ⅱ and glycogen synthase 3 [J]. j Biol Chem ,1987,262(29) :14042214048.
  • 8Van Wauw e J, H , aefner B. et al. Glycogen synthase kinase 3 as drugt a.,get : from w allf low ert o cent er of at tent ion [ J] . Drug New BPerspeet , 2003, 16 : 557565.
  • 9Beurel, E. Michalek, S. M. Jope, IL S. et aL Glycogen synthase kinase 3 beta mediates high glucose - induced ubiquitination and proteasome degradation of insulin receptor substrate[ J]. The Journal of endocri- nology. 2010 Aug;206(2) :171 -181.
  • 10Greene MW , Gorofalo RS. et al. Positive and negative regulatory role of insulin receptor substrate and ( IBS 21 and IR22) serine/threo- nine phosphory2 lation [ J]. Biochemistry ,2002,41:708227091.

同被引文献28

  • 1Ji-Wu Han,Department of Gastroenterology,The 4th Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China Xiao-Rong Zhan,Xin-Yu Li,Bing Xia,Yue-Ying Wang,Jing Zhang,Department of Endocrinology,First Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China Bao-Xin Li,Department of Pharmacology,State Key Laboratory of Biomedicine and Pharmacology,Harbin Medical University,Harbin 150001,Heilongjiang Province,China.Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats[J].World Journal of Gastroenterology,2010,16(48):6111-6118. 被引量：22
  • 2Moo TA, Rubino F. Gastrointestinal surgery as treatment for type 2 diabetes. Curt Opin Endocrinol Diabetes Obes, 2008, 15(2) : 153-158.
  • 3Buchwald H, Estok R, Fahrbach K, et al. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery, 2007,142(4) :621-635.
  • 4Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev, 2007,87(4) : 1409-1439.
  • 5Kawano K, Hirashima T, Mori S, et al. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long- Evans Tokushima Fatty (OLETF) strain. Diabetes, 1992,41 ( 11 ) : 1422-1428.
  • 6Meier JJ, Nauck MA, Schmidt WE, et al. Gastric inhibitory polypeptide: the neglected incretin revisited. Regul Pept, 2002,107(1-3) : 1-13.
  • 7Ring DB, Johnson KW, Henriksen EJ, et al. Selective glycogen synthase kinase-3 inhibitors potentiate insulin avtivation of glucose transport and utilization in vitro and vivo. Diabetes, 2003,52(3) :588-595.
  • 8DePaula AL, Macedo AL, Rassi N, et al. Laparoscopic treatment of type 2 diabetes mellitus for patients with a body mass index less than 35. Surg Endosc, 2008,22(3) :706-716.
  • 9Portha B, Lacraz G, Kergoat M, et al. The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes.'? Mol Cell Endocrinol, 2009,297 (1-2) : 73-85.
  • 10Moiler DE. New drug targets for type 2 diabetes and the metabolic syndrome. Nature, 2001,414(6865) : 821-827.

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西南军医
2011年 第5期

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