摘要
目的观察膝关节骨性关节炎(OA)血清和关节液中脂联素(ADP)的变化及临床意义。方法采用酶联免疫吸附法检测75例膝关节OA患者和50名健康体检者的血清和关节液ADP、白细胞介素-1(IL-1)和基质金属蛋白酶-3(MMP-3)水平,分析其与关节损伤程度的关系。结果 OA患者关节液ADP水平明显高于对照组,差异有统计学意义(t=3.14,P<0.05),血清和关节液IL-1和MMP-3浓度也明显高于对照组,差异有统计学意义(t分别=2.87、2.59、2.64、2.37,P均<0.05)。关节液ADP水平与软骨损伤分度呈正相关(r=0.54,P<0.05)。结论关节液ADP检测可作为诊断早期关节损伤的指标,优于常规指标IL-1和MMP-3。
Objective To explore the changes and significance of serum and joint fluid ADP level in osteoarthritis（OA） patients.Methods Serum and joint fluid ADP,IL-1 and MMP-3 level of 50 healthy persons and 75 OA patients were detected by ELISA method,and the relationship with arthroscopic cartilage injury scale was analyzed.Results The joint fluid ADP level of OA patients was higher than that of the control group（t=3.14,P〈0.05）;The serum and joint fluid IL-1,MMP-3 level of OA patients was higher than that of the control group（t=2.87,2.59,2.64,2.37,P〈0.05）;the joint fluid ADP level had positive correlation with arthroscopic cartilage injury scale（r=0.54,P〈0.05）.Conclusions Joint fluid ADP level examinations can be used for diagnosis of knee osteoarthritis and reflect joint damage degree,better than IL-1 or MMP-3.
出处
《全科医学临床与教育》
2011年第4期401-403,共3页
Clinical Education of General Practice
