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颅脑损伤患者血清泛素羧基末端水解酶-1水平变化及临床意义 被引量：1

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摘要 泛素羧基末端水解酶-1（ubiquitin carboxylterminal hydrolase L1,UCH-L1）是一类由223个氨基酸组成的半胱氨酸水解酶[1],在神经系统中分布广泛,也是一种重要的功能酶。已往关于UCH-L1的临床研究集中于各种神经退行性疾病,
作者 揭波盛
机构地区 常山县人民医院神经外科
出处 《全科医学临床与教育》 2011年第4期420-421,共2页 Clinical Education of General Practice
关键词 羧基末端 水解酶 颅脑损伤患者 临床意义 水平变化 泛素 神经退行性疾病 血清
分类号 R651.1 [医药卫生—外科学]
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参考文献8

  • 1Blyth B,Farahvar A,He H,et al.Elevated Serum Ubiquitin Carboxy-terminal Hydrolase L1is Associated with Abnor-mal Blood Brain Barrier Function after Traumatic Brain In-jury. Journal of Neurotrauma . 2011
  • 2Papa L,Akinyi L,Liu MC,et al.Ubiquitin C-terminal hy-drolase is a novel biomarker in humans for severe traumatic brain injury. Critical Care Medicine . 2010
  • 3Vajtr D,Benada O,Kukacka J,et al.Correlation of ultra-structural changes of endothelial cells and astrocytes occur-ring during blood brain barrier damage after traumatic brain injury with biochemical markers of BBB leakage and in-flammatory response. Physiological Research . 2009
  • 4Hergenroeder GW,Moore AN,McCoy JP Jr,et al.Serum IL-6:a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury. J Neuroinflammation . 2010
  • 5Gong B,Leznik E.The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders. Drug News and Perspective . 2007
  • 6Coleman, M.P,R.R. Ribchester.Programmed axon death, synaptic dysfunction and the ubiquitin proteasome system. Current Drug Targets . 2004
  • 7Pickart CM.Mechanisms underlying ubiquitination. Annual Review of Biochemistry . 2001
  • 8Liu Y,Fallon L,Lashuel HA,et al.The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson’s disease susceptibility. Cell . 2002

同被引文献37

  • 1吴娜,夏佐中.白细胞介素6与脑损伤的研究进展[J].国际神经病学神经外科学杂志,2005,32(4):373-376. 被引量：10
  • 2Douglas-Escobar M, Weiss MD. Biomarkers of hypoxic-ischemic encephalopathy in newborns[ J]. Front Neurol,2012,3 : 1 - 50.
  • 3Ling X, Sylvester K. Proteomics and biomarkers in neonatology [ J ]. Neoreviews ,2011,12 (10) : e585 - e591.
  • 4Chiesa C, Pellegrini G, Panero A, et al. Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia[J]. Eur J Clin Invest,2003,33 (4) :352 - 358.
  • 5Streijger F, Oerlemans F, Elleubroek BA, et al. Siructural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit [ J]. Brain Res ,2005,157 (2) :219 - 234.
  • 6Gazzolo D, Miehetti F. Perinatal S100B protein assessment in human uneonventional biological fluids: a minireview and new perspectives [ J ]. Cardiovase Psychiatry Neurol, 2010, 2010 : 703563.
  • 7Gazzolo D, Marinoni E, DiIorio R, et al. Urinary S100B protein measurements: a tool for the early identification of hypoxie- ischemic eneephalopathy in asphyxiated full-term infants[ J]. Crit Care Med ,2004,32( 1 ) : 131 - 136.
  • 8Risso FM, Serpero LD, Zimmermann LJ, et al. Perinatal asphyxia: kidney failure does not affect S100B urine concentrations[ J]. Clin Chim Acta,2011,413 (1/2) : 150 - 153.
  • 9Qian J,Zhou D,Wang YW. Umbilical artery blood S100 13 protein: a tool for the early identification of neonatal hypoxic-ischemic encephalopathy[ J]. Eur J Pediatr,2009,168 ( 1 ) :71 - 77.
  • 10Gazzolo D, Frigiola A, Bashir M, et al. Diagnostic accuracy of S100B urinary testing at birth in full-term asphyxiated newborns to predict neonatal death [ J]. PLoS ONE ,2009,4 (2) : e4298.

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全科医学临床与教育
2011年 第4期

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