CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关

Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers

利用meta分析的方法探讨吸烟人群中CYP1A1基因多态位点与肺癌易感性的关系.获取1986年至2010年2月pubmed等数据库中有关CYP1A1基因Ile462Val和Msp1位点多态性与肺癌易感性关系的研究结果,统计对应的吸烟者或非吸烟者的研究数据,运用RevMan4.2软件对各研究原始结果进行统计处理,计算合并OR值及95%可信区间.按照纳入标准,最终入选文献共有29篇病例对照研究,吸烟者中Ile462Val位点与肺癌发生显著相关,基因型Val/Val+Ile/Val比Ile/Ile的合并OR值为1.29(95%CI∶1.03,1.63),P<0.05,而该位点在非吸烟者中及Msp1位点在两种人群的分析结果均不具统计学意义.上述结果提示,对目前相关研究结果的Meta分析显示,吸烟者中CYP1A1基因Ile462Val位点多态性与肺癌易感性之间存在一定相关性.

All of the publications were eligible from Medline and Pubmed databases and the information about relationship between CYP1A1 Ile462Val and Msp1 polymorphisms and lung cancer risk among smokers was summarized.Meta-analysis was performed using RevMan 4.2.29 case-control studies were available.For Ile462Val,meta-analysis revealed that the risk of lung cancer among smokers with Val/Val and Ile/Val genotypes was 1.29 times of those with Ile/Ile genotype（P〈0.05） by the random effects model.There was no significant correlation between Msp1 and lung cancer among smokers or non-smokers.These results suggest that CYP1A1 Ile462Val polymorphism is related to the susceptibility of lung cancer among smokers.