三七对骨重建偶联中细胞因子IGF-1,IL-6表达影响

Expression and effects of panax on cytokines IGF-1,IL-6 in coupling of bone remodeling

目的:探讨三七对骨重建偶联中细胞因子IGF-1和IL-6的表达影响。方法:通过三七总皂苷被小白兔吸收后,将其血清放入体外成骨细胞和破骨细胞共培养体系,观察培养体系中IGF-1和IL-6的变化。结果:三七组的成骨细胞含量和IGF-1含量均高于对照组,并随着三七的浓度升高而逐渐升高;破骨细胞含量和IL-6含量均低于对照组,并随着三七的浓度升高而逐渐降低。结论:三七能够促进成骨细胞增长,促进成骨细胞分泌IGF-1,抑制成骨细胞分泌IL-6,从而抑制破骨细胞增长,抑制骨吸收功能,达到治疗骨质疏松症的作用。

Objective： To explore expression and effects of panax on cytokines IGF-1, IL-6 in coupling of bone remodeling. Methods： After panax were absorted by rabbits, put serum in vitro into osteoblasts and osteoclasts co-culture system, then observe the change of IGF-land IL-6 in co-culture system. Results： Osteoblasts content and IGF-1 levels in panax notoginseng were higher than control group, and increasing with the increasing of panax concentration. Osteoclasts content and IL-6 levels were lower than control group, and decreasing with the decreasing of panax concentration. Conclusion： Panax could promote growth of bone cells and osteoblasts secrete IGF-1, at the same time, which also could inhibition of osteoblasts secrete IL-6, so that it inhibit thes growth of osteoclasts and resorption function, then get to the role of treatment of osteoporosis.