中西医结合治疗原发性肾病综合征临床观察

Treatment of Patients with Primary Nephrotic Syndrome by Combining Traditional Chinese and Western Medicine

目的:观察中西医结合治疗原发性肾病综合征的疗效。方法:将76例原发性肾病综合征患者按入院顺序随机分为对照组37例和治疗组39例,对照组给予激素常规治疗,治疗组在对照组基础上加用黄芪白花蛇舌草汤口服,疗程4周。观察两组总体疗效、主要生化指标的改变以及副作用发生情况。结果:治疗组总有效率和完全缓解率分别为87.18%和46.15%,显著高于对照组78.38%和35.14%(P<0.05);治疗组治疗后24hUpro、血脂TC、TG显著降低,血清TP、ALB明显升高,LDL、HDL、BUN、Scr等指标亦有明显改善,与对照组比较,差异有统计学意义(P<0.05);治疗组在减轻水肿、降低感染率、减少复发等方面优于对照组,差异有统计学意义(P<0.05)。结论:中西医结合治疗原发性肾病综合征能显著降低尿蛋白,升高血清白蛋白,减轻激素的副作用,明显优于单纯西药治疗。

Objective：To observe the efficacy of the treatment of primary nephrotic syndrome by combining traditional Chinese and Western medicine.Methods：76 cases of primary nephritic syndrome were randomly divided into control group（37 cases）and treatment group（39 cases）according to admission order.The control group received conventional treatment with glucocorticoid,while the treatment group with astragalus-diffusa soup and glucocorticoid.After 4 weeks,the overall efficacy,the changes of several major biochemical indicators and side effects of all the patients were observed.Results：The total effective rate and complete remission rates in treatment group were 87.18% and 46.15%,significantly higher than 78.38% and 35.14% in control group（P〈0.05）.After treatment,in the treatment group,24h Upro,TC,TG significantly decreased,TP,ALB increased significantly,LDL,HDL,BUN,Scr and other indicators had also improved significantly,compared with the control group,the difference was statistically significant（P〈0.05）.The treatment group superior to the control group in reducing edema and reducing infection rates and the recurrence rate,the difference was statistically significant（P〈0.05）.Conclusion：The treatment of primary nephrotic syndrome by combining traditional Chinese and Western medicine,significantly reducing urinary protein,increasing serum albumin,and reducing the side effects of hormone,could be significantly better than western medicine purely.