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Axl基因在肿瘤进展中的作用 被引量：3

Role of Axl gene in tumor progress
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摘要 Axl(Anexelekto)为受体酪氨酸激酶亚家族成员之一,与配体Gas6结合可激活Axl的酪氨酸激酶活性,激活下游信号转导途径。参与细胞黏附与识别、细胞增殖、抗凋亡、凝血、炎症反应等过程。Axl基因异常表达在多种肿瘤的发生、发展过程中发挥重要作用,包括抑制肿瘤细胞凋亡,参与肿瘤性血管生成及侵袭等病理过程。 Axl（Anexelekto） is a subfamily member of receptor tyrosine kinases.Once combining with its ligand Gas6,the tyrosine kinase activity of Axl and downstream signaling pathways are activated.Axl participates in the process of cell adhesion and recognition,proliferation,antiapoptotic,clotting,and inflammatory reaction.Aberrant expression of Axl plays an important role in the pathogenesis and development in various tumors,including inhibition of tumor apoptosis,involvement of tumor angiogenesis and invasion.
作者 李琦 张声
机构地区 福建医科大学附属第一医院病理科
出处 《国际病理科学与临床杂志》 CAS 2011年第4期328-332,共5页 Journal of International Pathology and Clinical Medicine
基金 福建医科大学第一临床学院学科带头人培养对象专项基金(JXK200724)~~
关键词 AXL 受体酪氨酸激酶 肿瘤 Axl receptor tyrosine kinase tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献39

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共引文献11

同被引文献25

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国际病理科学与临床杂志
2011年 第4期

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