Wnt信号通路在强直性脊柱炎发病过程中的作用

The Role of Wnt Signaling Pathways in the Onset Process of Ankylosing Spondylitis

强直性脊柱炎(AS)是一种病因复杂、发病隐匿且具有潜在致残性的血清阴性脊柱关节病。其关节病理变化过程可以归结为附着点炎、骨侵蚀、骨赘形成三个阶段,骨赘形成致关节融合强直最终导致残疾。AS的骨赘形成过程及机制尚不清楚。经典Wnt和骨形态发生蛋白信号通路在调节成骨细胞功能及骨形成中发挥重要的协同作用。

Ankylosing spondylitis（AS）is a complex,insidious and potentially disabling form of seronegative spondyloarthritis.Its pathological process can come down to enthesitis,bone erosion and syndesmophyte formation,syndesmophyte formation cause joint fusion stiffness and ultimately lead to disability.The process and mechanism of syndesmophyte formation remains unclear.The currently increasing studies indicate that the classic Wnt and bone morphogenetic protein signaling pathways play an important synergy in regulating the osteoblast function and bone formation.