摘要
起源于早期前体T细胞(ETPs)的急性淋巴细胞白血病(ETP-ALL)造成大约20%罹患该病的儿童死亡,其生物学的异质性尚未认识。CD5低表达与CD1a和CD8表达阙如并存即符合ETP基因型,ETP-ALL致癌的转录因子与典型T-ALL病例表达无明显差异,不能以此来分开这两种白血病亚型。ETP-ALL患者对标准加强化疗反应差,预后不佳,缓解失败或血液学复发的累积发生率以ETP-ALL亚组显著为高。
About 20% of children with acute T cell-acute lymphoblastic leukaemia（T-ALL）originating from early T-cell precursors（ETPs）（ETP-ALL）succumb to the disease,suggesting an unrecognized biological heterogeneity.Weak CD5 expression combined with lack of CD1a and CD8 expression could be diagnosed as ETP-ALL,but no clear distinction between ETP-ALL and typical T-ALL cases could be made and used to identify subtypes of T-ALL on the basis of the expression of certain oncogenic transcription factors.Patients of ETP-ALL showed a poor prognosis with use of standard intensive chemotherapy,and the cumulative incidence of remission failure or hematologic relapse was significantly higher.
出处
《医学综述》
2011年第15期2305-2307,共3页
Medical Recapitulate
