儿童期难治性癫痫的治疗进展

Advances of Intractable Epilepsy in Childhood

如何合理应用抗癫痫药物治疗儿童期难治疗癫痫以获得满意的治疗效果,已经引起广大医务工作者的广泛注意。新型抗癫痫药的问世和应用,给儿童癫痫患者的治疗带来了希望和更多的选择。虽然没有证据显示新型抗癫痫药比传统抗癫痫药更有效,但许多研究已经证明它们的抗痫谱广,药物相互作用和不良反应少,耐受性和安全性较传统抗癫痫药好。神经营养因子、抗氧化剂既有脑保护作用,又有抗癫痫作用。迷走神经刺激术、脑电刺激术、冷却法、放射疗法等物理疗法为难治性癫痫的治疗拓宽新的思路。改良后的生酮饮食疗法的临床实用性值得进一步研究。

Reasonable use of drugs in the treatment of epilepsy in childhood for satisfacfory effed,has drawn attention of the broad masses of medical workers.The appearance and application of new antiepileptic drug,brought hope to the children with epilepsy to entitle them more chances for selection.Although there was no evidence that new type of anti-epileptic drugs have more effective than the traditional antiepileptic drugs,many studies have documented they have a broad antiantiepileptic spectrum,nearly no interactions with other drugs,and fewer side effects.Neurotrophic factors integrat both cerebral protective effect and antiepileptic effect.The physiotherapy including vagus nerve stimulation,brain stimulation,cooling,radiation therapy extended our thought for treating intractable epilepsy.The research showed that the utilization of ketogenic diet in clinic is worth of further study.