手足口病临床诊疗研究进展

Research Progress in Clinical Diagnosis and Treatment of Hand,Foot and Mouth Disease

手足口病由小RNA病毒科肠道病毒属引起,病原以EV71为主,易感人群主要为2～5岁儿童。咽拭子和肛拭子反转录-聚合酶链反应法同时检查可提高EV71阳性检出率。目前无特异性治疗方法,以支持疗法为主,绝大多数患者可自愈。轻症患者中药治疗效果满意,重症患者的主要治疗药物为甘露醇、丙种球蛋白等。在此综述目前该疾病的诊疗研究进展,总结救治经验,为手足口病疫情暴发时如何采取有效的抢救措施提供理论依据。

Main pathogen of hand,foot and mouth disease（HFMD） caused by a small RNA virus family intestinal virus is EV71,the major susceptible people of which is children aged 2-5.Throat swab and rectal swab RT-PCR method for the simultaneous examination can improve the positive detection rate of EV71.Currently there is no specific treatment,but only supporting therapy,while the absolute majority of patients can heal by themselves.Chinese medicine treatment for patients with mild sympotoms is satisfactory;treatments for severe HFMD,according to domestic research reports,are mannitol and intravenous gamma globulin etc..Here is to review the current research progress in the diagnosis and treatment of the disease,summarize the experience,and provide a theoretical basis for effective rescue measures for HFMD outbreak.