感染性疾病抗感染治疗前后血清抗核抗体滴度的变化

Clinical Observation on the Relationship between Infection and Serum Level of Antinuclear Antibody

目的观察47例各种感染性疾病患者经抗感染治疗前后血清ANA滴度的变化。方法选取我院诊治的47例各种感染性疾病患者为研究对象,以间接免疫荧光法检测患者治疗前及治疗后24、、8周的ANA滴度,观察其滴度的变化。结果在47例不同感染性疾病患者中,ANA阳性率达27.7%,其中年龄≥60岁患者阳性率为47.4%,<60岁者阳性率14.3%(P<0.01)。细菌感染者阳性率22.9%,病毒感染者阳性率41.7%(P<0.01)。治疗后2、4、8周时ANA滴度较治疗前显著降低。结论感染可致患者ANA滴度显著升高,而经抗感染治疗后ANA滴度可随时间延长而降低或恢复正常。

Objective To observe the variation of serum level of antinuclear antibody（ANA）before and after treatment in 47 patients with different infectious diseases.Methods 47 patients with different infectious diseases were selected as objects.Before and 2,4,8 weeks after receiving efficient anti-infection treatment,serum ANA titers were detected using indirect imunnofluorescence method.Results Among the 47 patients,13 were ANA positive,with an overall positivity rate of 27.7%.Specifically,the positivity rate of patients ≥60 yrs was 47.4%,60 yrs 14.3%（P0.01）,bacterial infection 22.9%,virus infection 41.7%（P0.01）.The ANA titers decreased significantly 2,4,and 8 weeks after treatment,respectively.Conclusion Infection can cause a significant elevation of serum ANA titer,which can then decrease significantly or return to normal with time after effective anti-infection therapy.