丹皮多糖PSM2b-A的结构研究

Structure Investigation on PSM2b-A,A Polysaccharide of Moutan Cortex

研究了从中药丹皮(Moutan Cortex)中得到的酸性多糖PSM2b-A的化学结构。实验结果表明PSM2b-A由鼠李糖、阿拉伯糖、葡萄糖、半乳糖、甘露糖和少量蛋白质、糖醛酸组成。甲基化分析、部分酸水解、高碘酸氧化和smith降解等化学方法和IR1,3C NMR试验进一步表明PSM2b-A为以(1→6)(、1→4)连接为主链的、带有少量分支的结构复杂的杂多糖,在分子间氢键的作用下能形成高级结构。该多糖化学结构为首次报道。

The structure of an acidic polysaccharide PSM2b-A extracted from the cortex of Paeonia suffruticosa Andr.has been investigated.The result showed that PSM2b-A was composed of L-Rha,L-Ara,D-Xyl,D-Glc,D-Gal and D-Man containing uronic acid and traces of protein.By using chemical techniques such as methylation analysis,partial acidic hydrolysis,periodate oxidation,Smith degradation and IR,13C NMR spectroscopy,the structure of PSM2b-A was deduced characteristic of a low branched heteropolysaccharide with a linkage of（1→6）,（1→4） as a main chain which could further form into higher structure by means of intermolecular hydrogen bond.