西南远志中皂苷类成分的分离与鉴定

Isolation and Identification of Saponins from Polygala crotalarioides

采用乙醇回流提取,通过硅胶柱、HPD100大孔树脂、Sephadex LH-20、半制备HPLC分离方法,运用现代谱学方法从西南远志中分离并鉴定了4个齐墩果酸型皂苷类化合物,均为顺反异构体,所用实验方法并不能有效分开。他们分别是:(E/Z)-PolygalasaponinXLIV(1),3-O-β-D-glucopyranosyl presenegenin 28-O-β-D-galactopyr-anosyl-(1→4)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-[6-O-acetyl-β-D-glucopyranosyl-(1→3)]-{4-O-([E/Z)-3,4-dimethoxycinnamoyl}]-β-D-fucopyranosyl ester(2),(E/Z)-PolygalasaponinXXX(3)(,E/Z)-senegasaponin C(4),均为首次从该种植物中分离得到。

Four oleanane-type compounds were isolated from EtOH extraction of Polygala crotalarioides Buch.Ham.They were cis-trans-isomers,can not be separated by us.According to the physical and chemical characteristics and spectral parameters,the structures of these compounds were identified as（E/Z）-PolygalasaponinXLIV（1）,3-O-β-D-glucopyranosyl presenegenin 28-O-β-D-galactopyranosyl-（1→4）-β-D-xylopyranosyl-（1→4）-α-L-rhamnopyranosyl-（1→2）-[6-O-acetyl-β-D-glucopyranosyl-（1→3）]-{4-O-[（E/Z）-3,4-dimethoxycinnamoyl]}-β-D-fucopyranosyl ester（2）,（E/Z）-PolygalasaponinXXX（3）,（E/Z）-senegasaponin C（4）,respectively.It was the first time to report that these compounds were isolated from P.Crotalarioides.