内脂素与多囊卵巢综合征相关研究进展

The Development of Study on Relationship Between Visfatin and Polycystic Ovary Syndrome

内脂素(visfatin)是近年发现的脂肪细胞因子,主要分布在脂肪细胞的细胞核和细胞质中,能调控内脏脂肪细胞的分化和成脂作用及胰岛素的敏感性。国外研究已证实,卵泡颗粒细胞分泌内脂素,其分泌水平受某些激素的影响。多囊卵巢综合征(PCOS)是一种严重影响女性生育的内分泌代谢失调性疾病,胰岛素抵抗、肥胖及生殖内分泌失调是其主要临床特征,这使内脂素与PCOS的发病机制紧密联系。综述内脂素与PCOS的相关研究。

Visfatin is a newly discovered novel adipocytokine, that mainly distributions in the fat cells of the nucleus and the cytoplasm. It can regulate the differentiation and adipogenic effect of visceral fat cells and insulin sensitivity. It has been confirmed that ovarian granulosa cells secrete visfatin, which can be affected by certain hormones. Polycystic ovary syndrome is an endocrine and metabolic disorders that seriously impacts on female reproductive. Its main clinical features are insulin resistance, over-weight and the reproductive endocrine and metabolic abnormalities. That makes visfatin closely linked to the pathogenesis of polycystic ovary syndrome. Related researches between visfatin and polycystic ovary syndrome are summarized as following.