摘要
目的应用视功能测定的方法观察MK-801对激光视网膜损伤的治疗作用。方法用氦氖激光造成大鼠视网膜损伤模型,治疗组照后即刻肌注MK-801(2mg/kg),通过检测视网膜电流图(electroretinogram,ERG)b波幅值的变化,观察MK-801的治疗作用。结果统计分析结果表明,MK-801治疗组的b波幅值要显著高于损伤对照组和生理盐水注射组(P<0.05)。结论 MK-801能有效地保护激光照后大鼠视网膜的功能。
Objective To study therapeutic effect of MK-801 on laser-induced retina injury by examining visual function.Methods Eyes in Wistar rats model were exposed to helium-neon laser and then treated with intramuscular injection of MK-801（2 mg/kg） or normal saline（controls）.Electroretinogram（ERG） was taken for the rat eyes to observe their changes in amplitude of b-wave and therapeutic effects of MK-801.Results Compared to that in control group,amplitudes of b-wave of ERG in MK-801-treated group were significantly higher than those in control group with normal saline（P0.05）.Conclusion MK-801 has therapeutic effect on laser-induced retina injury in rats.
出处
《首都公共卫生》
2011年第4期150-153,共4页
Capital Journal of Public Health
基金
国家自然科学基金资助项目(81000685
81072239)
关键词
视网膜
激光
损伤
视功能
治疗
Retina
Injury
Laser
Visual function
Therapy
Wistar rat
