超敏C反应蛋白、同型半胱氨酸与脑卒中严重程度及日常生活活动能力相关性分析

Correlation between High Sensitive C Reactive Protein and Homocysteine with the Severity of Stroke and Activities of Daily Life

目的:探讨血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)与脑卒中严重程度、转归及ADL能力的相关性。方法:129例脑卒中患者(卒中组)应用乳胶增强散色比浊法测定发病≤24 h、30 d及6个月时血清hs-CRP及Hcy水平,并与97例正常人(对照组)比较。应用美国国立卫生院神经功能缺损评分(NIH stroke scale,NIHSS)检测卒中组患者神经功能缺损程度;Barthel指数(BI)评分评定ADL能力;6个月应用改良Rankin评分评定神经功能缺损程度及转归。结果:卒中组在发病≤24 h及30 d时与对照组比较,hs-CRP及Hcy均显著升高;与NIHSS及BI呈正相关(P<0.01)。发病6个月后卒中组hs-CRP及Hcy与Rankin评分仍呈正相关(P<0.05),其他指标无统计学意义。结论:测定发病时血清中hs-CRP及Hcy水平可反映脑卒中神经功能受损的严重程度,对患者ADL预后及病情转归的预测有重要的临床价值。

Objective：To analyze the correlation between the high sensitive C reactive protein（hs-CRP） and homocysteine（Hcy） with the severity of stroke and activities of daily life（ADL）.Methods：The hs-CRP and Hcy levels were determined ≤24 h,30 days and 6 months after stroke attack and compared with those in 97 normal controls.The NIH stroke scale,Barthel index（BI） and Rankin scales were recorded.Results：hs-CRP and Hcy levels ≤24 h and 30 days after stroke attack were significantly increased in stroke group as compared with control group,and were positively correlated with NIH stroke scale and BI（P0.01）.There was no significant difference in hs-CRP and Hcy levels between stroke group and controls.At the 6th month after stroke attack,hs-CRP and Hcy levels were positively correlated with Rankin scales（P0.05）.Conclusion：Determination of hs-CRP and Hcy levels at the stroke attack can show the severity of stroke,and can predict the ADL.