双三唑席夫碱哒嗪酮衍生物的合成及其生物活性

Synthesis and Biological Activities of Novel Bistriazolyl-3(2H)-pyridazinones

设计合成了9种未见文献报道的双三唑席夫碱哒嗪酮化合物。用1H NMR、13C NMR、IR及元素分析表征结构。生物活性初步结果表明,在500 mg/L浓度下部分化合物对黄瓜花叶病毒(CMV)、小麦赤霉病菌(G.zeae)、辣椒枯萎病菌(F.oxysporum)和苹果腐烂病菌(C.mandshurica)有一定抑制作用。

Nine novel pyridazinone derivatives containing 1,2,4-triazolo and Schiff base were synthesized.Their structures were characterized by 1H NMR,13C NMR,IR and elemental analyses.The preliminary bioassay showed that,under 500 mg/L concentrations,some of them exhibited certain anti-cucumber mosaic virus（CMV）,G.zeae,F.oxysporum and C.mandshurica activities and fungicidal activities.